abstract：:CCN2 plays an important role in the pathogenesis of hypertrophic scars (HTSs). Although CCN2 is involved in many fibroproliferative events, the CCN2 induction signaling pathway in HTSs is yet to be elucidated. Here, we first investigated the effect of the mitogen-activated protein kinases (MAPKs) on CCN2-induced α-smo...

journal_title：Archives of dermatological research

authors： Hu X,Wang H,Liu J,Fang X,Tao K,Wang Y,Li N,Shi J,Wang Y,Ji P,Cai W,Bai X,Zhu X,Han J,Hu D

更新日期：2013-07-01 00:00:00

abstract：:The glycolytic enzyme α-enolase is a plasminogen-binding protein that is generally found in the cytosolic compartment. However, α-enolase can also be expressed on cell surfaces following an inflammatory stimulus via an unknown mechanism. We investigated the effects of Streptococcus sanguinis (S. sanguinis) and the ser...

journal_title：Archives of dermatological research

authors： Cho S,Zheng Z,Cho SB,Choi MJ,Lee KH,Bang D

更新日期：2013-04-01 00:00:00

abstract：:Currently, there are no accurate and simple methods available to measure this risk of atrophy in patients treated with topical glucocorticosteroids. In the present clinical trial, we validated a new score (Dermaphot(®) score) to assess the atrophogenic potential of glucocorticosteroids. 36 healthy adult volunteers wer...

journal_title：Archives of dermatological research

authors： Hofmann M,Salgo R,Aschoff R,Luger TA,Meurer M,Bräutigam M,Thaci D

更新日期：2013-04-01 00:00:00

abstract：:Lichen planus (LP) is a chronic inflammatory, T cell-mediated autoimmune skin disease. Innate immunity could explain the interplay between environmental triggers and the autoimmune cascade leading to disease development. Toll-like receptors (TLRs) are important components of the innate immune system, with no previous ...

journal_title：Archives of dermatological research

authors： Salem SA,Abu-Zeid RM,Nada OH

更新日期：2013-03-01 00:00:00

abstract：:The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) in the reconstruction of skin equivalent (SE). H&E staining showed that SE containing hyaluronic acid (HA) or HA and CCC had a thicker epidermis than the control SE. Immunohistochemical staining showed that p63 was mainly present at the b...

journal_title：Archives of dermatological research

authors： Kim J,Jeong HS,Li H,Baek KJ,Kwon NS,Yun HY,Choi HR,Park KC,Kim DS

更新日期：2013-01-01 00:00:00

abstract：:When determined in vitro, the SPF of certain commercial sunscreen products can be lower than the SPF indicated on the label. The study of the composition of this type of product enabled us to note that the majority contained substances reputed to have anti-inflammatory properties. This effect is shown by inhibiting th...

journal_title：Archives of dermatological research

authors： Couteau C,Chauvet C,Paparis E,Coiffard LJ

更新日期：2012-12-01 00:00:00

abstract：:The use of microalgae in the skin care market is already established although the scientific rationale for their benefit was not clearly defined. In this work, the biological activities of dermatologic interest of the water extract from the microalga Botryococcus braunii (BBWE) were evaluated by a battery of in vitro ...

journal_title：Archives of dermatological research

authors： Buono S,Langellotti AL,Martello A,Bimonte M,Tito A,Carola A,Apone F,Colucci G,Fogliano V

更新日期：2012-11-01 00:00:00

abstract：:Tranilast is used clinically as a drug for hypertrophic scars or keloids. Recently, the roles of keratinocytes in the pathogenesis of those conditions have been noted. Therefore, we first examined the effect of tranilast on the cell growth of normal human keratinocytes. A cell growth assay demonstrated that the cell n...

journal_title：Archives of dermatological research

authors： Kubo M,Zhao Y,Moriguchi T

更新日期：2012-11-01 00:00:00

abstract：:Marie Unna Hereditary Hypotrichosis 1 (MUHH1; OMIM 146550), a rare monogenic condition characterized by the development of sparse, twisted hair or complete hair loss, is the consequence of mutations located in the hairless (HR) gene. We have identified a 68-year-old Hungarian woman affected by alopecia universalis and...

journal_title：Archives of dermatological research

authors： Farkas K,Nagy N,Kinyó A,Kemény L,Széll M

更新日期：2012-10-01 00:00:00

abstract：:Keloid is a complex condition with environmental and genetic risk-contributing factors. Two candidate genes, TGFβ1 and SMAD4, located in the same signaling pathway are highly expressed in the keloid fibroblast cells. In a case-control design, TGFβ1 haplotypes showed association with the risk of keloid in the present s...

journal_title：Archives of dermatological research

authors： Emami A,Halim AS,Salahshourifar I,Yussof SJ,Khoo TL,Kannan TP

更新日期：2012-09-01 00:00:00

abstract：:Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic-pituitary-adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-r...

journal_title：Archives of dermatological research

authors： Cemil BC,Canpolat F,Yilmazer D,Eskioğlu F,Alper M

更新日期：2012-03-01 00:00:00

abstract：:Rosacea is a chronic skin disorder, characterized by persistent painful facial flushing and often accompanied by papules and pustules. To investigate the mechanism of facial flushing in rosacea, acetylcholine was administered by iontophoresis to a 10-mm diameter site in the forehead of 31 patients with rosacea and in ...

journal_title：Archives of dermatological research

authors： Drummond PD,Su D

更新日期：2012-03-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by...

journal_title：Archives of dermatological research

authors： Speeckaert R,Colebunders B,Boelaert JR,Brochez L,Van Acker J,Van Wanzeele F,Hemmer R,Speeckaert MM,Verhofstede C,De Buyzere M,Arendt V,Plum J,Delanghe JR

更新日期：2011-12-01 00:00:00

abstract：:Enhancement strategies are necessary to improve the dermal/transdermal bioavailability of drugs applied to the skin due to its amazing barrier, the stratum corneum. Strategies to overcome this barrier, thus improving drug release to the skin include the use of penetration enhancers, specific delivery systems, supersat...

journal_title：Archives of dermatological research

authors： Pierre MB,Dos Santos Miranda Costa I

更新日期：2011-11-01 00:00:00

abstract：:Vitiligo is an acquired clinical conundrum, characterized by white areas on the skin due to loss of functional melanocytes. Various studies demonstrated that vitiligo is associated with fewer risk of skin cancer but no exact molecular explanation for this interesting observation has been described. This article review...

journal_title：Archives of dermatological research

authors： Feily A,Pazyar N

更新日期：2011-11-01 00:00:00

abstract：:Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induce...

journal_title：Archives of dermatological research

authors： Hiramoto K,Orita K,Yamate Y,Sato EF,Okano H,Nishikawa K,Inoue M

更新日期：2011-07-01 00:00:00

abstract：:Exposure to ultraviolet (UV) irradiation has detrimental effects on skin accompanied by the increased metabolism of hyaluronan (HA), a linear polysaccharide important for the normal physiological functions of skin. In this study, the modulation of human keratinocyte response to UVB irradiation by HA (970 kDa) was inve...

journal_title：Archives of dermatological research

authors： Hašová M,Crhák T,Safránková B,Dvořáková J,Muthný T,Velebný V,Kubala L

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to screen the antioxidant, anti-hyaluronidase, and anti-elastase activity of the lyophilized juice of Cucumis sativus fruit (CSLJ). The CSLJ was subjected to DPPH and superoxide radical scavenging assay in reference to butylated hydroxytoluene. The hyaluronidase and elastase inhibitory assay ...

journal_title：Archives of dermatological research

authors： Nema NK,Maity N,Sarkar B,Mukherjee PK

更新日期：2011-05-01 00:00:00

abstract：:Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between these two cell types. Recent studies suggest...

journal_title：Archives of dermatological research

authors： Magina S,Esteves-Pinto C,Moura E,Serrão MP,Moura D,Petrosino S,Di Marzo V,Vieira-Coelho MA

更新日期：2011-04-01 00:00:00

abstract：:To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...

journal_title：Archives of dermatological research

authors： Rho HS,Ahn SM,Hwang JS

更新日期：2011-04-01 00:00:00

abstract：:Keloid disease (KD) is a quasineoplastic fibroproliferative tumour of unknown origin causing a progressive, recurrent dermal lesion. KD is not homogeneous in nature and shows phenotypic structural differences between its distinct peripheral margins compared to its centre. The keloid margin is often symptomatically mor...

journal_title：Archives of dermatological research

authors： Hollywood KA,Maatje M,Shadi IT,Henderson A,McGrouther DA,Goodacre R,Bayat A

更新日期：2010-12-01 00:00:00

abstract：:Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix (ECM) in the dermis. It is a late spreading skin overgrowth and may be considered a plastic surgeon's nightmare. In nature, curcuminoid is composed of curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (bDMC). Curcumino...

journal_title：Archives of dermatological research

authors： Hsu YC,Chen MJ,Yu YM,Ko SY,Chang CC

更新日期：2010-12-01 00:00:00

abstract：:Patients with atopic dermatitis (AD) often present with dry skin, and the reduced secretion of sebum may be responsible for the impaired skin barrier function. A sebum check film enables the patient to self-evaluate the skin sebum content. This study compared the sebum check film with a sebumeter. The skin sebum conte...

journal_title：Archives of dermatological research

authors： Furuichi M,Makino T,Matsunaga K,Hamade E,Yokoi H,Shimizu T

更新日期：2010-11-01 00:00:00

abstract：:Delayed pressure urticaria (DPU) is characterized by deep dermal wheals that appear in response to a local continuous pressure. Although it has been reported to complicate as many as 40% of cases of Caucasian patients with chronic urticaria, no definitive cases of Asian/Japanese patients have been reported in English ...

journal_title：Archives of dermatological research

authors： Morioke S,Takahagi S,Iwamoto K,Shindo H,Mihara S,Kameyoshi Y,Hide M

更新日期：2010-10-01 00:00:00

abstract：:The aim of this study was to investigate the presence and density of the nerve fibre-marker protein gene product 9.5 (PGP 9.5), with immunohistochemistry, in skin from patients with hidradenitis suppurativa (HS). Punch biopsies were obtained from 16 patients; 10 with involvement of the groin and six with axillary dise...

journal_title：Archives of dermatological research

authors： Sartorius K,Emtestam L,Lapins J,Johansson O

更新日期：2010-08-01 00:00:00

abstract：:Glycerol, widely used as humectant, is known to protect against irritants and to accelerate recovery of irritated skin. However, most studies were done with topical formulations (i.e. emulsions) containing glycerol in relatively high amounts, preventing drawing conclusions from direct effects. In this study, acute che...

journal_title：Archives of dermatological research

authors： Atrux-Tallau N,Romagny C,Padois K,Denis A,Haftek M,Falson F,Pirot F,Maibach HI

更新日期：2010-08-01 00:00:00

abstract：:Wound infections with multi-drug resistant bacteria increase morbidity and mortality and have considerable socioeconomic impact. They can lead to impaired wound healing, resulting in rising treatment costs. The aim of this study was to investigate an ex vivo human wound infection model. Human full-thickness skin from ...

journal_title：Archives of dermatological research

authors： Steinstraesser L,Sorkin M,Niederbichler AD,Becerikli M,Stupka J,Daigeler A,Kesting MR,Stricker I,Jacobsen F,Schulte M

更新日期：2010-07-01 00:00:00

abstract：:Myotonic muscular dystrophy (MMD) is caused by an abnormal function of RNA-binding proteins (RBP) resulting in DNA spliceopathy. A case of a patient, with MMD multiple basal and squamous cell carcinomas and dysplastic nevi, is described. The association between MMD and non-melanoma skin cancer has been reported before...

journal_title：Archives of dermatological research

authors： Zemtsov A

更新日期：2010-04-01 00:00:00

abstract：:In skin inflammation, vascular endothelial growth factor (VEGF) and CXCL-8/IL-8 play an important role and are produced by activated keratinocytes. Extracts from Ginkgo biloba leaves (GBE), widely used in phytotherapy, have been reported to exert antioxidant and anti-inflammatory properties in the skin. We therefore e...

journal_title：Archives of dermatological research

authors： Trompezinski S,Bonneville M,Pernet I,Denis A,Schmitt D,Viac J

更新日期：2010-04-01 00:00:00

abstract：:In many skin diseases such as Demodex folliculitis, rosacea- or steroid-induced rosacea Demodex mites are present in abundance and are at least partially held responsible for causing these disorders. Although it is known that these diseases respond well to tetracyclines, it is unclear if this is due to the antiinflamm...

journal_title：Archives of dermatological research

authors： Borgo SN,Sattler EC,Hogardt M,Adler K,Plewig G

更新日期：2009-10-01 00:00:00

abstract：:The case of a 44-year-old man with a primary cutaneous large B-cell non-Hodgkin's lymphoma of the scalp is reported. His mother died of gastric lymphoma and his sib brother is in a 20-year remission of T-cell lymphoma. The patient presented with a 16-year history of occipital and parietal alopecia and a recently worse...

journal_title：Archives of dermatological research

authors： Colovic N,Jurisic V,Terzic T,Atkinson HD,Colovic M

更新日期：2009-10-01 00:00:00

abstract：:Paraneoplastic pemphigus patients (PNP) develop a group of autoantibodies, among which those against envoplakin and periplakin are almost always found. Epitope mapping has indicated that the linker subdomains of the proteins harbor the major antigenic sites recognized by PNP sera. In order to detect specific autoantib...

journal_title：Archives of dermatological research

authors： Huang Y,Li J,Zhu X

更新日期：2009-10-01 00:00:00

abstract：:The goal of this study is to investigate commercially available cosmetics (foundations, skin care creams) which also claim to include a sun protection factor (SPF). Are these products, which are not considered sunscreen products, helpful or could they be harmful? Using an in vitro method, we tested the effectiveness o...

journal_title：Archives of dermatological research

authors： Séhédic D,Hardy-Boismartel A,Couteau C,Coiffard LJ

更新日期：2009-09-01 00:00:00

abstract：:Serotonin is a monoamine acting as a neuromediator in the central and peripheral nervous system. Recently, serotonin has also been shown to influence T- and B-cell function. The serotonin transporter is central in the regulation of the serotonergic system and widely expressed on cells of the immune system. A functiona...

journal_title：Archives of dermatological research

authors： Mössner R,Stiens G,König IR,Schmidt D,Platzer A,Krüger U,Reich K

更新日期：2009-07-01 00:00:00

abstract：:The expression of matrix metalloproteinase-2 was observed to be significantly upregulated in psoriasis. The aim of this study was to associate the DNA polymorphic variants in MMP-2 promoter gene with psoriasis and/or with psoriasis phenotypes related to psoriasis and comorbid heredity. In the total of 582 Czech Caucas...

journal_title：Archives of dermatological research

authors： Vasku V,Bienertova Vasku J,Slonková V,Kanková K,Vasku A

更新日期：2009-07-01 00:00:00

abstract：:Recently, we reported that UVB-activated indole-3-acetic acid (IAA) induces the apoptosis of G361 human melanoma cells. In the present study, we used IAA and visible light combinations to treat B16F10 melanoma-implanted nude mice using an experimental intense pulsed light (IPL) therapy model. We first investigated whe...

journal_title：Archives of dermatological research

authors： Kim SY,Kim MK,Kwon SB,Na JI,Park KC,Kim DS

更新日期：2009-04-01 00:00:00

abstract：:Genetic differences are involved in the development of lupus erythematosus (LE). Skin lesions are influenced by environmental triggers such as ultraviolet light, temperature, and chemical stresses, and the patterns of skin lesion are variable in cutaneous LE such as systemic LE (SLE), chronic discoid LE (CDLE), subacu...

journal_title：Archives of dermatological research

authors： Furukawa F,Muto M

更新日期：2009-01-01 00:00:00

abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...

journal_title：Archives of dermatological research

authors： Nancy AL,Yehuda S

更新日期：2009-01-01 00:00:00

abstract：:Accumulating evidence shows that tight junctions (TJs) in the granular layer contribute to the epidermal barrier, suggesting that the regulation of TJ assembly in keratinocytes may provide a clue to understanding the role of barrier formation in epidermis. In this study, we investigated the behavior of TJ-related mole...

journal_title：Archives of dermatological research

authors： Yamamoto T,Saeki Y,Kurasawa M,Kuroda S,Arase S,Sasaki H

更新日期：2008-10-01 00:00:00

abstract：:A novel point mutation in a patient with vascular type Ehlers-Danlos syndrome is herein reported. The patient experienced pneumothorax and multiple arterial troubles during the past 10 years. The patient's hand skin was atrophic, and a paper-like atrophic scar was seen. The collagen microfibrils from the patient's ski...

journal_title：Archives of dermatological research

authors： Okamoto O,Ando T,Watanabe A,Sato F,Mimata H,Shimada T,Fujiwara S

更新日期：2008-10-01 00:00:00